PhD student positions

Your university hospital in the heart of Munich

We are the Klinikum rechts der Isar (MRI) Hospital of Munich Technical University (TUM) and a reliable employer of around 6,600 people. Being a university hospital, we not only look after our patients but, based on our motto “Knowledge Creates Cures” (Wissen schafft Heilung), we are also engaged in research and teaching, enjoying an excellent national as well as international reputation.

The Department of Internal Medicine II, at the Technische Universität München (TUM) and the Institute of Translational Cancer Research and Experimental Cancer Therapy at TUM and the German Cancer Research Center offer

PhD student positions (m/f/d)

in
Pancreatic Cancer Research and Computational Biology/Bioinformatics
at the Center for Translational Cancer Research (TranslaTUM) in Munich.
We are deploying genetic models to study molecular, immunological and translational aspects of pancreatic cancer. We utilize these systems to uncover molecular mechanisms as well as inflammatory and immune pathways that are required for tumor initiation and -progression in vivo (e.g. Nature Cancer 2022 doi: 10.1038/s43018-021-00326-1, Cancer Discovery 2021, 11: 3158–3177, Nature 2018, 554:62-68; Nat. Rev. Cancer 2017, 17:239-253; Nat. Commun. 2016, 7:10770; Nat Med. 2014, 20:1340-7). During the past decade, our lab has generated a comprehensive resource of pancreatic primary tumors and primary cell cultures. Multiple NGS methods and biological readouts have been performed to decipher the molecular makeup and phenotypes of these tumors. The advertised projects focus on (1) understanding the molecular mechanisms linking tumor heterogeneity and oncogenic signaling, (2) unraveling the chronobiology of pancreatic cancer and its impact on treatment response and resistance, and (3) computational approaches to investigate tumor subtype specific genetic and drug interactions in close collaboration with the Theis lab at Helmholtz Center Munich.

The successful candidates will have the opportunity to:

• Gain important insights into clinically relevant aspects of cancer development and therapy
• Learn and apply a wide spectrum of genetic, molecular and cell biology, biochemical as well as immunological and bioinformatics techniques to study translational aspects of cancer (e.g. Cre/loxP and Flp/FRT based dual- and triple recombinase systems, organoid culture, orthotopic transplantations of cells/organoids, CRISPR/Cas9, molecular in vivo imaging, quantitative proteomics/phosphoproteomics, multiple transcriptomics and genomics approaches, single cell sequencing, histocytometry)
• Set up bioinformatics platforms and develop computational pipelines for the analysis of bulk and single cell RNA- and DNA-sequencing datasets, advanced barcoding and proteomics/phosphoproteomics
• Integrate these datasets with molecular (WES, WGBS, lcWGS, ChIPseq, ATACseq), phenotypic (e.g. histology), drug screening and clinical information
• Aid researchers select and use computational and statistical tools relevant to their single cell sequencing projects
• Interact within a diverse and multidisciplinary environment of biologists, clinicians, computational scientists and mathematicians within the TranslaTUM.

Your profile:

We are looking for exceptional self-motivated bright individuals with a Diploma or Masters degree in bioinformatics, biochemistry, biology, molecular/translational medicine or related subjects. Previous exposure to and experience with basic biochemical and molecular biology techniques, proteomics or bioinformatics as well interests in molecular aspects of cancer research is essential. Due to the interdisciplinary framework and close collaboration between wet-lab and computational scientists, good communicative skills are essential.

We offer you:

• We are an enthusiastic and international team and offer intensive training and mentoring
• A varied and professionally demanding position in a state-of-the-art working environment
• Comprehensive on-the-job training provided by experienced and qualified colleagues
• The opportunity to take part in internal and external professional development courses
• An opportunity to work in the city centre of Munich on Max-Weber-Platz with good access to public transport systems and benefits in the form of specially discounted public transport tickets
• You may be entitled to a special allowance to make up for the higher cost of living in Munich (“Ballungsraumzulage”)
• Employee saving schemes and company pension system
• Compatibility of family and work through our in-house kindergarten/crèche, additional childcare in family rooms, mobile KidsBox day care facility and childcare during school holidays
• 65% TV-L E13 plus attractive benefits offered to public- sector employees

If the candidates’ suitability for the position in question is equal, severely disabled applicants shall be given preference. Interview-related costs can, unfortunately, not be reimbursed.

We look forward to your application!

Please submit your complete application documents by e-mail quoting number 03_037 in one pdf file by e-mail to:

dieter.saur
tum.de
Univ.-Prof. Dr. med Dieter Saur
Institut für Experimentelle Tumortherapie
Klinik und Poliklinik für Innere Medizin II
Klinikum rechts der Isar der Technischen Universität München
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