Postdoctoral Scientist

The Klinikum rechts der Isar university hospital of the Technical University of Munich is a major European center of medical care and education and teaching with 1.161 beds and around 6.000 employees. Every year around 60,000 patients benefit from inpatient and around 250.000 patients from outpatient care. The hospital is a supra-maximal care home that covers the entire spectrum of modern medicine. Since 2003, the Klinikum rechts der Isar is an institute of public law of the Free State of Bavaria.

The
Klinik und Poliklinik für Innere Medizin II
of the Technical University of Munich (TUM) invites applications for a

Postdoctoral Scientist Position (f/m/d) Drug Vulnerabilities of Pancreatic Cancer Subtypes

The Collaborative Research Center (CRC) 1321 „Modelling and Targeting Pancreatic Cancer”, a research consortium aiming to improve understanding and therapeutic strategies of the disease, is founded by the German Research Foundation (DFG). As part of the CRC1321, we are offering a postdoctoral position, which will be hosted at the Klinikum rechts der Isar of the Technical University of Munich.

Pancreatic cancer is almost always fatal and has the highest mortality rate of all solid tumor entities. Although the existence of PDAC subtypes with distinct biology and therapeutic vulnerabilities is undisputed, clear subtype specific therapies are lacking. To define subtype specific dependencies, a pharmacological screen using a large murine pancreatic cancer cell-line repository as well as human pancreatic cancer organoid biobank will be conducted. Subtype-specific targets will be mechanistically analyzed across species in vitro and in vivo and results will be used to develop a translational therapeutic pipeline for precision oncology.

The position is embedded into the excellent interdisciplinary and international pancreatic cancer research environment of the TUM (Biederstädt, Gut, 2020; Mueller et al., Nature, 2018; Maresch et al., Nature Communications, 2017; Schneider et al., Nature Reviews Cancer, 2017; Rad et al., Nature Genetics, 2015; Mazur et al., Nature Medicine, 2015; Schönhuber et al. Nature Medicine, 2014), which provides access to state-of-the-art infrastructure, including established robotics and liquid handling instruments for the drug screen.

Your profile

We are seeking a self-motivated and independent scientist with a PhD degree in biomedicine, biology, biochemistry or related fields with a specific interest in translational pancreatic cancer research. The successful candidate will contribute to the pharmacological cell-based screening efforts of the CRC1321 and the mechanistic analysis of novel therapeutic vulnerabilities. Therefore, experience in drug screen technologies and bioinformatics data analysis (R or Python) are especially welcome. Experience and/or interest in working with automation systems and liquid handling instruments are highly desirable. Experiences in basic and advanced cellular and molecular biology techniques are mandatory. The Postdoc is expected to be highly collaborative and pass on skills and knowledge to other team members and visitors. He/she will be involved in the supervision of PhD students and undergraduates. Excellent communication skills for scientific discussion is indispensable.

We give priority to severely disabled applicants with essentially equal qualifications. Payment according to tariff (TV-L).

We are looking forward for your application!

Application requirements

1. Cover letter indicating current and future research interests and expected availability date
2. CV (Curriculum Vitae)
3. Description of past research experience and accomplishments
4. Selected reprints of publications
5. Names of three references

Please send your application in one pdf file to :

PD Dr. med. Günter Schneider

Klinik und Poliklinik für Innere Medizin II
Klinikum rechts der Isar der Technischen Universität München
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